For me, there is one truly memorable first line:
"Many years later, as he faced the firing squad, Colonel Aureliano Buendía was to remember that distant afternoon when his father took him to discover ice."It is one first line that really sticks with me.
- One Hundred Years of Solitude
It was also the first line of one of my college application essays. When I was applying to college, one of the essay options for the University of Chicago was an improv piece. We were given a number of different things that we had to incorporate into the essay (I can't remember them all off the top of my head, but one was The Complete Works of Shakespeare) including that line. It was a wonderful challenge and the fact that the school had an essay option like that left no doubt in my mind that Chicago was my first choice school.